High-Purity Chlorinated Pyrrolidinophenone Reagent
What is 4-Cl-α-PVP?
Buy 4-Cl-α-PVP (4-Chloro-α-pyrrolidinopentiophenone) is a synthetic molecule of the substituted cathinone and pyrrolidinophenone classes. It is a structural analogue of α-PVP (Flakka), distinguished by the substitution of a chlorine atom at the 4-position (para) of the phenyl ring. At Chemssupply.eu, we provide high-purity 4-Cl-α-PVP in a stable crystalline salt form. As a premier EU chemical supplier, we ensure our reagents meet the analytical requirements for forensic toxicology and neuropharmacological research.
How It Works | Buy 4-Cl-α-PVP online in Europe.
In professional laboratory settings, 4-Cl-α-PVP is studied for its potency as a selective norepinephrine-dopamine reuptake inhibitor (NDRI). Peer-reviewed research available on NCBI PubMed suggests that para-chlorination significantly alters the molecule’s lipophilicity and binding kinetics compared to non-halogenated counterparts.
Researchers utilize 4-Cl-α-PVP to map its affinity at the dopamine transporter (DAT) and norepinephrine transporter (NET). Its unique chemical signature is vital for GC/MS calibration, liquid chromatography, and Structure-Activity Relationship (SAR) mapping within the pyrrolidinophenone series.
Benefits and Features
Distinct Halogenated Profile: The para-chloro substitution provides a robust chemical marker, facilitating precise differentiation from 4F-α-PVP or α-PHP in toxicological screenings.
HPLC Verified Purity: We guarantee 98%+ verified purity, ensuring that analytical baselines are free from synthesis-related impurities or unreacted precursors.
Superior Thermal Stability: Provided as a stable crystalline salt (typically HCl), ensuring consistent performance in in-vitro assays and long-term storage.
Detailed Analytical Signature: Exhibits a specific fragmentation pattern for high-resolution mass spectrometry, as documented in European Union Early Warning System (EWS) reports.
REACH & ECHA Compliant: Fully documented according to the latest European Chemicals Agency (ECHA) distribution and safety standards.
Safety and Handling
When you order PVP online in Europe, maintaining strict laboratory safety protocols is mandatory.
In-Vitro Laboratory Use Only: 4-Cl-α-PVP is intended strictly for forensic, analytical, and academic research. It is not for human or animal consumption.
PPE Protocols: Researchers must wear nitrile gloves, laboratory coats, and eye protection. All handling should take place in a certified, well-ventilated fume hood.
High Potency Caution: Due to the known potency of pyrrolidinophenones, precision analytical scales and micro-measurement protocols are essential.
Documentation: A comprehensive Material Safety Data Sheet (MSDS) is included with every purchase to ensure compliant safety management in your facility.
Usage Guidelines and Storage
Optimal Storage: Store in a cool, dry, and dark environment (<25°C). To maintain peak chemical integrity for over 12 months, keep the container airtight. Storage at -20°C is recommended for maintaining the salt form’s stability.
Analytical Application: Ideal for LC-MS/MS reference testing, receptor binding assays, and investigating the metabolic stability of chlorinated cathinones.
Disposal: Dispose of all chemical waste in accordance with your local hazardous-waste protocols.
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