High-Purity 4-Hydroxytryptamine wholesale supplier

4-HO-MET (4-Hydroxy-N-methyl-N-ethyltryptamine), commonly referred to as Metocin, is a synthetic molecule of the tryptamine class and a structural analogue of psilocin (4−HO−DMT). It is distinguished by its asymmetric N-substitution, containing one methyl and one ethyl group. At Chemssupply.eu, we provide 4-HO-MET in a highly stable fumarate salt form, optimized for laboratory longevity. As a premier EU chemical supplier, we ensure our reagents meet the rigorous standards required for advanced neuropharmacological and forensic research.

How It Works

In professional research environments, 4-HO-MET is utilized to investigate the modulation of the serotonergic system.

Receptor Affinity: Research available on NCBI PubMed identifies 4-HO-MET as a potent 5−HT 2A receptor agonist.

Pharmacodynamics: Researchers study this compound to understand how the addition of anethyl group (compared to the dimethyl substitution in psilocin) alters binding kinetics and metabolic pathways.

Analytical Use: Due to its sensitive phenolic group, 4-HO-MET is an essential subject for studying oxidation prevention in tryptamine solutions and serves as a vital reference for LC-MS/MS and GC/MS calibration.

Chemical Properties
IUPAC Name: 3-[2-[ethyl(methyl)amino]ethyl]-1H-indol-4-ol
Molecular Formula: C13 H18 N2O
Molecular Weight: 246.31 g/mol
Chemical Structure: The structure consists of a tryptamine core with an acetoxy group at the 4-position and N-methyl and N-ethyl substitutions on the nitrogen atom.

Research Applications

4-HO-MET is a cornerstone reagent for several key scientific domains:

Structure-Activity Relationship (SAR): Evaluating the influence of asymmetric N-alkyl chains on the 4-hydroxyindole core.

Forensic Screening: Providing a reliable analytical signature for the European Union Early Warning System (EWS).

Neuroplasticity Studies: Investigating the “halo” of tryptamine activity on cortical neurons in in-vitro models.

Safety and Handling

When you order 4-HO-MET online in Europe, adhering to stringent safety protocols is mandatory.

In-Vitro Laboratory Use Only: This compound is intended strictly for forensic, analytical, and academic research. It is not for human or animal consumption.

PPE Protocols: Researchers must wear nitrile gloves, laboratory coats, and eye protection. All chemical transfers should be conducted in a certified fume hood to prevent accidental inhalation.

Documentation: A comprehensive Material Safety Data Sheet (MSDS) is included with every purchase to ensure compliant safety management.

Usage Guidelines and Storage

Optimal Storage: 4-hydroxy tryptamines are inherently sensitive to light and oxygen. Store in a cool, dry, and dark environment (<25°C). Storage at -20°C is highly recommended to prevent degradation and discoloration over time.

Analytical Application: Ideal for receptor binding assays, metabolic stability testing, and high-resolution mass spectrometry.

Disposal: Dispose of all chemical waste in accordance with your local hazardous-waste protocols.

Why Source from Chemssupply.eu?

Chemssupply.eu is the leading authority for institutions looking to buy 4-HO-MET online in Europe.

Direct EU Logistics: Dispatched from our internal warehouses to ensure no customs interference and rapid delivery to Germany, France, Italy, and Spain.

Analytical Transparency: Access batch-specific purity certificates and verified lab data for every order to ensure research reliability.

Secure Payment Infrastructure: We support Bank Transfers and privacy-focused Cryptocurrencies (BTC, ETH, XMR).

Professional Packaging: All orders are vacuum-sealed and shipped in discreet, neutral packaging to protect the chemical integrity of your reagents.