High-Purity 2-Amino-5-Aryloxazoline For Sale

Buy 4-MAR (4-Methylaminorex), historically known as “ICE,” is a potent stimulant and a structural derivative of aminorex. 4-MAR analogues are synthetic molecules characterized by a 2-amino-5-aryloxazoline core. At Chemssupply.eu, we provide professional-grade analogues such as 4,4′-DMAR and halogenated variants. As a leading EU-based chemical supplier, we ensure these reagents meet the analytical requirements for forensic toxicology and advanced neuropharmacological research.

Pharmacological Profile

In laboratory settings, 4-MAR analogues are researched for their profound interaction with the mammalian reward system. Unlike traditional amphetamines, the oxazoline ring provides a unique binding profile.

Monoamine Release: Peer-reviewed data on NCBI PubMed indicates that 4-MAR analogues act as potent releasing agents for Dopamine (DAT) and Norepinephrine (NET).

Serotonergic Activity: Certain derivatives, such as 4,4′-DMAR (Serotoni), exhibit a significant increase in Serotonin (SERT) releasing activity, making them a critical subject for studying serotonin syndrome risks in in-vitro models.

Duration and Stability: Research focuses on the prolonged half-life of these analogues compared to phenethylamines, attributed to the stability of the oxazoline ring against rapid enzymatic degradation.

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Technical Specifications & Purity

Core Structure: 2-amino-5-aryloxazoline

Halogenated Variants: Including 4-Fluoro and 4-Chloro derivatives for SAR mapping.

Purity: ≥98.0% (HPLC/GC-MS Verified)

Appearance: Fine crystalline salt or high-density powder.

Compliance: Fully documented according to the latest European Chemicals Agency (ECHA) safety and distribution standards (2026).

Key Research Areas
Structure-Activity Relationship (SAR): Evaluating how methyl or halogen substitutions on the phenyl ring alter receptor affinity and neurotoxicity.

Analytical Identification: Providing high-resolution reference data for the European Union Early Warning System (EWS) to assist in the detection of novel psychoactive substances (NPS).

Metabolic Pathway Mapping: Investigating the hepatic and renal processing of oxazoline-based stimulants.

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Safety and Handling Protocols

Due to the high potency of 4-MAR analogues, strict laboratory safety is mandatory:

In-Vitro Laboratory Use Only: These reagents are strictly not for human or animal consumption.

PPE: Nitrile gloves, safety goggles, and professional laboratory coats are required at all times.

Fume Hood Handling: All chemical transfers must occur in a certified, well-ventilated fume hood to prevent accidental inhalation.

Documentation: A comprehensive Material Safety Data Sheet (MSDS) is provided with every shipment.

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Usage and Storage Guidelines

Optimal Storage: Store in a cool, dry, and dark environment (<25°C). For long-term preservation of the salt form, storage at 4°C is recommended.

Disposal: Neutralize and dispose of all chemical waste in accordance with your local hazardous-waste protocols.